BACE crystal structure with hydroxy morpholine inhibitor
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BACE crystal structure with hydroxy morpholine inhibitor Descriptor: Beta-secretase 1, GLYCEROL, N-[(1S,2S)-1-[(3R,6R)-6-(cyclohexylmethoxy)morpholin-3-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide Authors: Timm, D.E. Deposit date: 2017-10-27 Release date: 2017-11-15 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences. J. Med. Chem., 60, 2017
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2017-10-27
