Genetic modifiers of Duchenne muscular dystrophy in Chinese patients-Supplementary Material

We genotyped <i>LTBP4</i> haplotypes and the<i> SPP1</i> promoter SNPs rs28357094, rs11730582, and rs17524488 in 326 patients registered in the neuromuscular database of The First Affiliated Hospital of Sun Yat-sen University. Kaplan-Meier curves and log-rank tests were used to estimate and compare median age at loss of ambulation, while Cox proportional hazard regression models were used as to analyze the effects of glucocorticoids treatments, <i>DMD</i> genotype, and <i>SPP1</i>/<i>LTBP4</i> SNPs on loss of ambulation.This study was approved by the ICE for Clinical Research and Animal Trial at First Affiliated Hospital of Sun Yat-sen University, and informed consent was obtained from each included patient prior to the survey.