Accurate classification of BRCA1 variants with saturation genome editing
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117159
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资源简介：
We describe the use of saturation genome editing to make and measure the effect of BRCA1 variants on protein function and splicing. We find the results accurately predict the clinical effects of variants. Saturation genome editing of the BRCA1 exons encoding the RING and BRCT domain.
创建时间：
2019-03-26
