Human primary mesothelial cells treated with TGF-β1 and with or without JPH203

The mesothelial-mesenchymal transition (MMT) of mesothelial cells has been recognized as a critical process during progression of peritoneal fibrosis (PF). Despite its crucial role in amino acid transport and metabolism, the involvement of LAT1 and the potential therapeutic role of its inhibitor, JPH203, in fibrotic diseases remain unexplored., , , # Human primary mesothelial cells treated with TGF-β1 and with or without JPH203

[https://doi.org/10.5061/dryad.6hdr7sr7h](https://doi.org/10.5061/dryad.6hdr7sr7h)

This dataset consists of RNA sequencing data from human primary mesothelial cells treated with TGF-β1, both with and without JPH203, an LAT1 inhibitor. The fastq files in this dataset correspond to raw sequencing reads from these experimental conditions, designed to explore the effects of JPH203 on gene expression under TGF-β1-induced fibrotic conditions. It includes fastq.gz files with raw sequencing reads and a supplementary **expression.xls** file that provides processed gene expression data.

## Description of the data and file structure

### RNA-seq Fastq Files:

The fastq.gz files contain paired-end reads and are organized by treatment group and replicate number. The filenames follow this structure:

* **T_X_R1.fastq.gz / T_X_R2.fastq.gz**: Control group (TGF-β1 treatment only), where 'T_X' indicates the replicate num...