Chiral Phosphine–Silver(I) Complex Catalyzed Enantioselective Interrupted Feist–Bénary Reaction with Ynones: The Aldol–Cycloisomerization Cascade
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https://figshare.com/articles/dataset/Chiral_Phosphine_Silver_I_Complex_Catalyzed_Enantioselective_Interrupted_Feist_Be_nary_Reaction_with_Ynones_The_Aldol_Cycloisomerization_Cascade/2153527
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资源简介：
Silver-catalyzed
interrupted Feist–Bénary reaction
is described for the efficient enantioselective synthesis of dihydrofuran
heterocycles. A new method has been developed for the silver(I)–(R)-BINAP complex mediated aldol–cycloisomerization
cascade reaction between ynones and 1,3-diketones to provide functionalized
dihydrofurans with moderate to good yields (up to 95%) and good to
excellent enantiomeric excess (up to 98%). The presence of an exocyclic
double bond and hydroxy group in the dihydrofuran products provides
wide scope for further structural manipulation.
创建时间：
2016-02-13
