WP3297 - EV release from cardiac cells and their functional effects - Homo sapiens

Summary of reported extracellular vesicle (EV) release from cardiac cells in culture and their functional effects. EV release has been reported in numerous cell lines and primary cultures, both at baseline and in response to stimuli. Transfer of EVs between cell types has been demonstrated as well as delivery of cargo.

Note that this pathway represents a review of multiple studies in multiple organisms. This pathway displays the human orthologs.

HUVEC: human aortic endothelial cell

HMEC-1: human microvascular endothelial cell

HASMC: human aortic smooth muscle cell

NRVM: neonatal rat ventricular myocyte.

Adapted from Danielson KM, Das S. Extracellular Vesicles in Heart Disease: Excitement for the Future? [Exosomes Microvesicles, 2014.](http://www.ncbi.nlm.nih.gov/pubmed/25429310).