Monocytes as endogenous immunologic biosensors: identification of inflammatory, adhesion, and mTOR-related signatures in psoriasis

Psoriatic monocyte singlets and doublets (MonD) have a distinct gene expression profile compared to singlet control monocytes. Furthermore, there is dysregulation of adhesion markers, tetraspanins, adipocytokines, and mTOR-related genes in singlets and doublets from both psoriatic and control individuals. Overall design: 12 individuals (8 healthy controls and 4 psorasis patients); 24 total samples (classical monocytes and monocyte doublets for each individual)