Transcriptional profiling of primary human peripheral blood monocytes isolated from neurologically unaffected controls and treated in culture with LPS or vehicle.. Transcriptional profiling of primary human peripheral blood monocytes isolated from neurologically unaffected controls and treated in culture with LPS or vehicle.

Inflammatory stimulation with lipopolysachharide (LPS) iduces a strong re-organization in the transcriptional program of human monocytes. We isolated peripheral blood monocytes from neurologically unaffected controls (n=8) and stimulated the monocytes in culture with LPS (1 ng/mL for 4 h) to investigate changes in gene expression upon LPS stimulation.