Hypoxia-induced changes in SUMO conjugation affect transcriptional regulation under low oxygen
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https://www.omicsdi.org/dataset/pride/PXD010946
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资源简介:
Recent data support that sumoylation, the covalent attachment of the Small Ubiquitin-related MOdifier (SUMO) to proteins, is involved in the activation of the hypoxic response and the ensuing signalling cascade. To gain insights into differences of the SUMO1 and SUMO2/3 proteome of HeLa cells under normoxia and cells grown for 48 h under hypoxic conditions, we employed endogenous SUMO-immunoprecipitation in combination with quantitative mass spectrometry (SILAC).
创建时间:
2019-04-03



