Fluoroalkyl-Substituted Cyclopropane Derivatives: Synthesis and Physicochemical Properties
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https://figshare.com/articles/dataset/Fluoroalkyl-Substituted_Cyclopropane_Derivatives_Synthesis_and_Physicochemical_Properties/12943450
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资源简介：
A series of all 12 cis- and trans-cyclopropanecarboxylic acids
and cyclopropylamines bearing CH2F, CHF2, and
CF3 substituents were synthesized
by different methods on a multigram scale. Dissociation constants
(pKa) and log P values were measured for the obtained compounds or their derivatives
to evaluate the influence of the type and relative position of fluoroalkyl
substituents on the acidity and lipophilicity of monofunctionalized
cyclopropanes. An analysis of the selected products by X-ray crystallography
was carried out to obtain a better insight into the observed differences
in physicochemical properties.
创建时间：
2020-09-01
