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Organocatalytic C(sp<sup>3</sup>)–H Functionalization of 5‑Methyl-2,3-dihydrofuran Derivatives with Trifluoropyruvates via a Sequential <i>exo</i>-Tautomerization/Carbonyl-Ene Process

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An organocatalytic C­(sp3)–H functionalization of 5-methyl-2,3-dihydrofuran derivatives with trifluoropyruvates was achieved via a sequential exo-tautomerization/carbonyl-ene process, providing the biologically important CF3-substituted 2,3-dihydrofurans in high yields. This method featured mild metal-free conditions, good chemoselectivity, and easy scalability.

创建时间:
2019-02-12
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