Comparison of mathematically ideal and displayed pairwise network distances between 42 human amine-binding GPCRs.

Pearson's correlations (R) and associated Z-scores (Z) and P-values (P) describing the similarity between the relative pairwise distances between 42 amine-binding GPCR domain sequences as assessed by (A) all shortest paths between ?log10(BLAST E-values), (B) the shortest paths between sequences as displayed by a two-dimensional graph layout algorithm, (C) the shortest paths between sequences in a Neighbor-Joining tree, and (D) the relative pairwise distances calculated from a multiple sequence alignment. Additionally, pairwise BLAST E-values and the graph layout algorithm correspond to a network thresholded at an E-value of 1��10?33. Note that the network layout (B) is a visual representation of the underlying distances in (A), while the tree (C) is a visual representation of the underlying distances in (D). A and D cannot be visualized exactly in fewer than N-1 dimensions.