Expression of EPHA4 in presomitic mesoderm

EPHA4 is expressed in the rostral halves of somites (inferred from mouse embryos) where it appears to play a role in the determination of somite boundaries through interaction with an Ephrin on an adjacent cell (inferred from zebrafish embryos in Durbin et al. 1998, Barrios et al. 2003 and from chicken embryos in Glazier et al. 2008). Expression of EPHA4 is directly activated by MESP2, which shows the same expression pattern (inferred from mouse homologs).

EPHA4在胚胎鼠的背索前半部分表达（据推测），似乎在通过与相邻细胞上的Ephrin相互作用，在确定背索边界方面发挥重要作用（据推测来自Durbin等人的1998年、Barrios等人的2003年和Glazier等人的2008年在鸡胚胎中的研究）。EPHA4的表达直接受MESP2激活，后者显示出相同的表达模式（据推测来自小鼠同源基因的研究）。