Data of Paroxetine mediate macrophage polarization by regulating GRK2-EP4-cAMP-pCREB signaling pathway in treating mice with DSS-induced colitis.rar

The human colon tissues and peripheral blood were approved for use by the Research Ethics Committee of First Affiliated Hospital of Anhui Medical University (No. 5101449, China) and written informed consents were provided by all patients and volunteers. Animal experimental protocols were approved by the Animal Experimental Ethics Committee of Anhui Medical University (No. 20220132) and strictly followed the ethical regulation of the Committee for Animal Care and Use at Anhui Medical University and the Guide for the Care and Use of Laboratory Animals (National Institutes of Health, the United States). All efforts were made to minimize animals’suffering and to reduce the number of animals used.