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Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury

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Figshare2025-07-15 更新2026-04-28 收录
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https://figshare.com/articles/dataset/Boosting_RNA_nanotherapeutics_with_V-ATPase_activating_non-inflammatory_lipid_nanoparticles_to_treat_chronic_lung_injury/29346935
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资源简介:
Lipid nanoparticles (LNPs) are a promising platform for mRNA delivery, but their use in inflammatory pulmonary diseases is limited by reactogenicity and suboptimal delivery. Here, the authors report a non-inflammatory LNP (NIF-LNP) exhibiting a 40-fold enhancement in lung protein expression without causing significant reactogenicity compared to LNPs containing commercial ALC-0315
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2025-07-15
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