Fragile X syndrome (FXS) is an inherited intellectual disability caused by a deficiency in Fragile X mental retardation 1 (Fmr1) gene expression. Recent studies have proposed the importance of cytopla

NIAID Data Ecosystem20

Table_4_Cytoplasmic Polyadenylation Element-Binding Protein 1 Post-transcriptionally Regulates Fragile X Mental Retardation 1 Expression Through 3′ Untranslated Region in Central Nervous System Neurons.XLSX

神经生物学

脆性X综合征病理机制

NIAID Data Ecosystem10

Comparison of WT and CHD2 haploinsufficent human interneuron progenitor (hMGE) and interneuron (hcIN) models, to define differences in RNA expression, genomic accessibility and histone 3 lysine 27 acetylation. Comparison of WT and CHD2 haploinsufficent human interneuron progenitor (hMGE) and interneuron (hcIN) models, to define differences in RNA expression, genomic accessibility and histone 3 lysine 27 acetylation

神经发育障碍分子机制

干细胞分化神经元模型

Background: Mutations in the chromatin remodeller CHD2 have been strongly associated with multiple neurodevelopmental disorders. However the precise function of CHD2 through neuronal development remai

NIAID Data Ecosystem20

Excitability is increased in hippocampal CA1 pyramidal cells of Fmr1 knockout mice

脆性X综合征病理机制

神经元电生理

Fragile X syndrome (FXS) is caused by a failure of neuronal cells to express the gene encoding the fragile mental retardation protein (FMRP). Clinical features of the syndrome include intellectual dis

Figshare2017-09-21 更新10

Molecular Mechanisms Regulating the Defects in Fragile X Syndrome Neurons Derived from Human Pluripotent Stem Cells

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