A Glial-Neuronal Circuit Controls Organismal Mitochondrial Stress to Prevent Neurodegeneration

To uncover whether activation of the UPRMT in non-neuronal cells of the nervous system can affect lifespan, we genetically activated the UPR MT in different glial subsets. Interestingly, we found that this activation in a small subset of glial cells, the cephalic sheath (CEPsh) glia provided robust organismal benefits, including prolonged lifespan and increased resistance to oxidative stress. To examine more global changes that occur upon activation of the UPR MT in CEPsh glia, we profiled gene expression changes using whole-animal bulk RNA-seq.