Transcriptional study of the temporal evolution after severe traumatic spinal cord injury (SCI) and neural progenitor cells (NPCs)-transplantation intervention.

This transcriptional profile analysis of total RNA samples from spinal cord homogenates of adult rats (Sprague Dawley) provides tissular (tought not cell-type specific) information of the critical time points after the injury from 1 to 8 weeks (acute, sub-acute and early-chronic and late-chronic stages) which conferred a wide temporal coverage making it ideal for studying the temporal dynamics of SCI. Furthermore, we have evaluated the impact of intramedullary acute or subacute transplantation of NPCs over the transcriptional regulation of the spinal cord tissue in order to define the functional outcomes of the NPCs therapy.本数据集针对成年斯普拉格-道利（Sprague Dawley）大鼠的脊髓匀浆总RNA样本开展转录组谱分析，可提供脊髓损伤后1至8周关键时间节点的组织层面（而非细胞类型特异性）信息，覆盖急性期、亚急性期、早慢性期与晚慢性期，时间跨度广泛，非常适合用于研究脊髓损伤（Spinal Cord Injury, SCI）的时序动态变化。此外，本研究还评估了髓内急性期或亚急性期神经前体细胞（Neural Progenitor Cells, NPCs）移植对脊髓组织转录调控的影响，以明确神经前体细胞移植疗法的功能结局。