scRNAseq of CD45+ cells within PDAC tumors treateted with CD40/ICB
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https://www.ncbi.nlm.nih.gov/sra/SRP260906
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Goal: determine how transcriptome of immune cells within the tumor microenvironment changes as a function of CD40 agonist and/or immune checkpoint blockade (anti-PD-1 AND anti-CTLA-4; "ICB") therapy Overall design: Mice were injected with KPC-derived pancreatic ductal adenocarcinoma (PDAC) cell line; mice were treated +/- CD40 agonist and +/- ICB; mice were sacrificed and CD45+ immune cells were FACS-isolated from the tumor microenvironment and sequenced
创建时间：
2020-08-11
