transcriptomic analysis of murine chronic proximal thoracic aortic aneurysms

This study aimed to establish a chronic proximal thoracic aortic aneurysm(cPTAA) model by combining periaortic elastase application and 90-day oral 3-aminopropionitrile fumarate salt(BAPN) administration.Transcriptome Sequencing was performed using Illumina Novaseq platform in 7 murine cPTAAs or 5 sham-operated proximal thoracic aortas.The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses revealed the differentially expressed genes were most enriched in immune and inflammation related pathways. 7 murine cPTAAs or 5 sham-operated proximal thoracic aortas underwent RNA-seq.