Analysis of altered mRNA expression profiles in the genetic hypercalciuric stone-forming (GHS) rat compared to normal SD rat

Urolithiasis is a common desease to human beings, and idiopathic hypercalciuria (IH) is an important risk factor of calcium urolithiasis, previous studies strongly suggested that the decreased tubular Ca2+ reabsorption played a key role of hypercalciuria. However,the molecular mechanism of IH-urolithiasis formation is still not completely elucidated. GHS rat is regarded as an ideal animal model of calcium urolithiasis, reveals many identical pathophysiologic characteristics with IH patients . We analyzed mRNA expression profiles of the kidney of GHS rat in order to find out the target genes and signaling pathways in the pathogenesis of IH.尿路结石症（Urolithiasis）是人类常见疾病，特发性高钙尿症（idiopathic hypercalciuria, IH）是钙性尿路结石症（calcium urolithiasis）的重要危险因素。既往研究表明，肾小管Ca²+重吸收降低在高钙尿症的发病中发挥关键作用。然而，IH相关尿路结石症的分子形成机制仍未完全阐明。GHS大鼠被认为是钙性尿路结石症的理想动物模型，其病理生理特征与IH患者高度一致。本研究通过分析GHS大鼠肾脏的mRNA表达谱，旨在挖掘IH发病机制中的关键靶基因及信号通路。