DNA methylome analysis of primary prostate cancer and pathologic lymph node metastases in patients with low and high Gleason score. DNA methylome analysis of primary prostate cancer and pathologic lymph node metastases in patients with low and high Gleason score

DNA-methylation profiles of primary tumors (PT) and paired synchronous lymph node metastases (LN) from Gleason Score (GS)-6/7a (n=20 LN-positive, n=20 LN-negative) and GS-9/10 patients (LN-positive n=20) after prostatectomy and lymphonodectomy were analyzed. Overall design: 5 groups were compared: GS-6/7a N0 primary tumors, GS-6/7a N1 primary tumors, GS-6/7a N1 lymph node metastasis, GS-9/10 N1 primary tumors, GS-9/10 N1 lymph node metastasis