Braak neurofibrillary stage specific ordinal regression analysis of miRNA expression data.

Ordinal logistic regression analysis (OLR) was implemented in order to detect miRNAs with monotonic expression patterns across Braak neurofibrillary stages. Braak stages were recorded during autopsy for each subject, and specific CSF subgroups consisted of stage 1 (n = 21), stage 2 (n = 21), stage 3 (n = 58), stage 4 (n = 37), stage 5 (n = 22), and stage 6 (n = 25) samples. For SER, Braak subcategories comprised stage 1 (n = 21), stage 2 (n = 27), stage 3 (n = 44), stage 4 (n = 31), stage 5 (n = 23), and stage 6 (n = 18) samples. Delta AIC () quantifies the information loss associated with using each model relative to the best approximating model. We report predictor variables with the lowest Akaike Information Criterion (AIC) and that satisfy assumptions of the OLR. p-Value* is unadjusted.