PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane

At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A), beta (PIP4K2B) and gamma (PIP4K2C) homodimers and heterodimers (Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015) phosphorylate phosphatidylinositol 5-phosphate (PI5P) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).<br><br>The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013), PIP4K2B (Rameh et al. 1997, Clarke and Irvine 2013) and PIP4K2C (Clarke and Irvine 2013, Clarke et al. 2015).

在质膜上，磷脂酰肌醇-5-磷酸4-激酶亚型2α（PIP4K2A）、β型（PIP4K2B）和γ型（PIP4K2C）的同源二聚体和异源二聚体（Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015）将磷脂酰肌醇-5-磷酸（PI5P）磷酸化为磷脂酰肌醇-4,5-二磷酸（PI(4,5)P2)。以下列出了上述蛋白质及其相应的文献引用：PIP4K2A（Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013）、PIP4K2B（Rameh et al. 1997, Clarke and Irvine 2013）和PIP4K2C（Clarke and Irvine 2013, Clarke et al. 2015）。