Supplementary Materials for JAPPL-00332-2025

Figure S1. Flowchart of screening and randomization of ITP patients. Figure S2. Specific effects of platelet counts and age on sleep latency, sleep disturbances, use of sleep medication, and subjective sleep quality. Note: (a-b, d) At platelet counts below 50×109/L, higher scores for sleep latency, sleep disturbances, and subjective sleep quality are observed across all age groups. (c) For platelet counts below 50×109/L, individuals older than 30 show a higher distribution of sleep medication scores (due to the small sample size and infrequent use of sleep medication among patients, this may not be representative). Figure S3. Specific contributing factors to sleep disturbances include insufficient sleep. Figure S4. Serotonin levels in the blood circulation between healthy individuals and ITP patients. Note: Serotonin (5-HT) levels in ITP patients are significantly lower than in healthy individuals (P<0.001).