Substrate-Controlled Michael Additions of Chiral Ketones to Enones
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https://figshare.com/articles/dataset/Substrate_Controlled_Michael_Additions_of_Chiral_Ketones_to_Enones/2228497
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资源简介：
Substrate-controlled Michael additions
of the titanium(IV) enolate
of lactate-derived ketone 1 to acyclic α,β-unsaturated
ketones in the presence of a Lewis acid (TiCl4 or SnCl4) provide the corresponding 2,4-anti-4,5-anti dicarbonyl compounds in good yields and excellent diastereomeric
ratios. Likely, the nucleophilic species involved in such additions
are bimetallic enolates that may add to enones through cyclic transition
states. Finally, further studies indicate that a structurally related
β-benzyloxy chiral ketone can also participate in such stereocontrolled
conjugate additions.
创建时间：
2014-12-05
