Danlu Tongdu Tablets: Safety evaluation and mechanism of hepatotoxicity in Sprague-Dawley rats

Based on the acute and chronic toxicity study, we further focused on the impact of Danlu Tongdu (DLTD) on the liver. At the end of 26 weeks of administration, 4 male rats were selected from the control group and the high-dose group respectively for transcriptome analysis. The selection criteria were random selection from the control group, the four rats selected from the high-dose. group showed pathological changes in the liver.基于急慢性毒性研究，我们进一步聚焦于丹鹿通督（Danlu Tongdu, DLTD）对肝脏的影响。给药26周结束时，我们分别从对照组与高剂量组中各选取4只雄性大鼠开展转录组分析。本次选取遵循如下标准：对照组采用随机选取方式，高剂量组选取的4只大鼠均存在肝脏病理改变。