L. pneumophilia Infection Diagnosed by tNGS. ERP123456

We report a case of a 34-year-old lady with multiply joint pain. With a positive result of anti-Ro antibody and right knee joint cavity effusion, autoimmune diseases were considered first. Later biliteral interstitial changes in her lungs and mediastinal lymphadenopathy were found after chest CT scanning. Empirical quinolone therapy was given although pathological examinations of blood, sputum and BALF did not find anything. Finally, Legionella pneumophila was only identified by tNGS. This case highlighted the timely use of tNGS, a new tool with fast speed, high accuracy and effective cost, could help to identify atypical infection and judge therapeutic effects.