Altered Expression Profiles of tRNA-derived fragments in relapsed/refractory multiple myeloma. Altered Expression Profiles of tRNA-derived fragments in relapsed/refractory multiple myeloma

tRNA related fragments(tRF) and tRNA halves(tiRNA) are novel class of short non-coding RNA derived from tRNAs. Using RNA sequencing, we evaluated the tRFs/tiRNAs expression profiles in relapsed/refractory multiple myeloma and multiple myeloma patients. Bioinformatics analyses indicated that tRFs/tiRNAs may be involved in the progression and drug-resistance of multiple myeloma. Overall design: tiRNA and tRF profiles in the bone marrow of relapsed/refractory multiple myeloma and multiple myeloma patients, using Illumina NextSeq 500 system.