Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=38b585199548f48dc832ed36c77c458c
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资源简介：
We introduce Chemical-crosslinking Assisted Proximity Capture (CAP-C), a method that utilizes multi-functional chemical crosslinkers with defined physical sizes to directly assess spatial distances between nuclear genomic sequences. CAP-C avoids limitations caused by extensive protein-DNA crosslinking in most in situ methods, and thus generates chromatin contact maps at high resolution with low background noise.
提供机构：
University of Connecticut Health Center
创建时间：
2022-02-20
