ICRmice Targeted loci. ICRmice

Scope：Iodine is an important trace element involved in the biosynthesis of thyroid hormones, while diet induced obesity is reported to perturb the trace elements metabolism balance. Herein, we studied the host-specific responses on thyroid function and gut microbiota modulation in the obese mice after the iodine treatment, and analyzed the possible causes for these responses.Methods and results:The obese mice were induced by high-fat diet, and the obese and normal mice received same dose of iodine (18 μg/kg/d) treatments continuously for 8 weeks. Iodine treatment in the obese mice showed a weight reducing effect, increased the thyroid hormones concentrations, altered the transcriptions of genes involved in thyroid hormones biosynthesis, and modulated the gut microbiota with increased abundance of pathogenic bacteria and decreased proportion of beneficial bacteria. However, totally different or even opposite response profiles were observed in normal host.Conclusions:Our work indicated obesity may exacerbate the risk of thyroid disease with a relatively safe dose of iodine, and the trance elements supplementation should take the individual differences into consideration