Promoter Capture Hi-C performed on A549 cells in a SARS-CoV2 infection timecourse

Here, A549 cells expressing the ACE2 receptor were infected with SARS-CoV2, and pCHi-C was performed at 0 (mock), 8 and 24 hours post-infection. This repository provides the raw pCHi-C sequence reads and downstream processed CHiCAGO data (Rds files). Overall design: A549 cells were crosslinked for promoter capture Hi-C (pCHi-C) experiments at zero (mock), eight and twenty-four hours post-infection with the SARS-Cov2 virus. pCHi-C libraries were generated and sequenced using paired-end NGS. This data accompanies the publication "Topoisomerase 1 inhibition therapy protects against SARS-CoV-2- induced inflammation and death in animal models".