Total Synthesis of Hyperforin
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https://figshare.com/articles/dataset/Total_Synthesis_of_Hyperforin/2137786
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资源简介：
A 10-step
total synthesis of the polycyclic polyprenylated acylphloroglucinol
(PPAP) natural product hyperforin from 2-methylcyclopent-2-en-1-one
is reported. This route was enabled by a diketene annulation reaction
and an oxidative ring expansion strategy designed to complement the
presumed biosynthesis of this complex meroterpene. The described work
enables the preparation of a highly substituted bicyclo[3.3.1]nonane-1,3,5-trione
motif in only six steps and thus serves as a platform for the construction
of easily synthesized, highly diverse PPAPs modifiable at every position.
创建时间：
2016-02-13
