Phenylacetaldehyde inhibits development of colorectal cancer. Phenylacetaldehyde inhibits development of colorectal cancer

Phenylacetaldehyde (PAA), a product of phenylalanine metabolism, is catabolized by microbiota and has demonstrated anticancer properties in breast cancer. As intestinal homeostasis is influenced by gut microbiome, we investigated the effect of PAA on colorectal cancer (CRC). In the study, we interrogated the mechanistic pathways induced by PAA treatment using RNA sequencing. Overall design: HCT-116 versus HCT-116 treated with PAA; RKO versus RKO treated with PAA.