Transcriptomic Profiling of Neonatal Offspring Hearts from Gestational Diabetes Mellitus Rat Models

Maternal diabetes during pregnancy has been associated with an increased risk of metabolic and cardiovascular disorders in the offspring. However, the underlying mechanisms by which intrauterine hyperglycemia impairs fetal cardiovascular development remain incompletely understood. Our study aimed to characterize the intrauterine environment in the setting of maternal diabetes mellitus and to identify the associated molecular alterations in the fetal heart. A rat model of intrauterine hyperglycemia was established to investigate transcriptomic changes in the cardiac tissue of offspring.