Dataset from Early-Onset Sepsis an NICHD/CDC Surveillance Study II

The primary purpose of this study was to determine rates of early-onset neonatal infection in term and preterm infants in the era of maternal intrapartum antibiotic prophylaxis to prevent vertical transmission of group B streptococcal disease. Early-onset infection comprises early-onset sepsis (EOS) and/or early-onset meningitis (EOM) and is defined as isolation of a pathogen from blood or cerebrospinal fluid (CSF) obtained within 72 hours of birth and provision of appropriate antibiotic treatment for 5 or more days (or <5 days if death occurs while receiving antibiotic therapy). The antimicrobial susceptibility patterns of organisms associated with EOS and EOM were evaluated. Case controls were also identified.