Neurocognition and functioning in adolescents at clinical high risk for psychosis

Introduction. This database includes the raw data linked with the paper “Neurocognitive Functioning of Adolescents at Clinical High Risk for Psychosis”. In this paper, we reported sociodemographic characteristics, family history of any DSM-5 psychiatric disorder, personal history of any DSM-5 psychiatric disorder, psychopathological assessment, and level of functioning. We aimed to  identify differences in overall and neurocognitive functioning in three groups of adolescent patients divided according to the semi-structured interview Comprehensive Assessment of At-Risk Mental States (CAARMS) criteria.

Methods Participants were divided into three groups: 1) adolescents with established Early Onset Psychosis (EOP), 2) adolescents meeting DSM-5 Attenuated psychotic Syndrome (APS) criteria and the attenuated psychotic symptoms subgroup of the Clinical High Risk for Psychosis (CHR-P), 3) adolescents with other DSM-5 psychiatric disorders who did not meet APS/EOP criteria.

Results . We found that non-CHR-P exhibited better functioning and performances than psychosis group in processing speed, forward and backward verbal digit span, visual attention, categorial fluency, executive functions, processing speed, and planning and attention. No differences emerged between non-CHR-P and CHR-P. CHR-P and psychosis groups differed in processing speed, in TMT-A, in BVN forward verbal digit span, visual attention, categorial fluency and in ROCF drawing from memory task.