Gene-SCOUT

Gene-SCOUT aims to find similar genes to a particular gene of interest where for each gene a unique signature is constructed. The method exploits associations derived from 450,000 exomes sequenced in the UK Biobank, as well as 120,000 samples of metabolomic data. For a given gene, its signature comprises a collection of associations between variants of the gene and phenotypic traits measured in the UK Biobank.Gene-SCOUT（Gene-SCOUT）旨在针对特定目标基因，检索与其相似的基因，其核心实现逻辑为每个基因构建唯一的特征签名。该方法利用源自英国生物库（UK Biobank）中45万份已测序外显子组以及12万份代谢组学数据样本的关联信息。对于给定基因，其特征签名由该基因的变异与英国生物库中测定的表型性状之间的一系列关联关系构成。