Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a
收藏Protein Data Bank Japan2024-10-30 更新2026-03-21 收录
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Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a Descriptor: 1-cyclopentyl-6-[[(2R)-1-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... Authors: Huang, Y.Y, Wu, Y, Luo, H.B. Deposit date: 2020-02-19 Release date: 2021-02-24 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.40003752238 Å) Cite: Identification of phosphodiesterase-9 as a novel target for pulmonary arterial hypertension by using highly selective and orally bioavailable inhibitors To Be Published
创建时间：
2020-02-19
