CD19 SPECIFIC CHIMERIC ANTIGEN RECEPTOR AND USES THEREOF
收藏国家林业和草原科学数据中心2023-02-12 更新2024-03-07 收录
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Described herein are chimeric antigen receptors (CAR). CARs are able to redirect immune cell specificity and reactivity toward a selected target exploiting the ligand-binding domain properties. In particular， the present invention relates to a chimeric antigen receptor in which extracellular ligand binding is a scFV derived from a CD19 monoclonal antibody， preferably 4G7. Further described herein are polynucleotides， vectors encoding said CAR and isolated cells expressing said CAR at their surface. Also described herein are methods for engineering immune cells expressing 4G7-CAR at their surface which confer a prolonged "activated" state on the transduced cell. The present invention is particularly useful for the treatment of B-cells lymphomas and leukemia.
提供机构：
国家林业和草原科学数据中心
创建时间：
2023-02-12
