BindingDB Entry 50042865: Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors.

Small molecule binding data for protein Apoptosis Signal-regulating Kinase 1 (ASK1), Aurora kinase B/Inner centromere protein, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 5, Dual specificity protein kinase TTK, Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 3, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor, Insulin-like growth factor I receptor, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase kinase kinase 1, Nuclear receptor subfamily 2 group C member 2, Platelet-derived growth factor receptor, Platelet-derived growth factor receptor beta, Protein kinase C theta type, RAF serine/threonine protein kinase, Receptor tyrosine-protein kinase erbB-4 (HER4), SRC, Serine/threonine-protein kinase PLK1, Tyrosine-protein kinase BMX, Tyrosine-protein kinase CSK, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase ZAP-70, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), and c-Jun N-terminal kinase, JNK, Uniprot L7RSL3, O14920, P00533, P04626, P06213, P06239, P07948, P08069, P08581, P09619, P10721, P11362, P15056, P16234, P17948, P22607, P27361, P33981, P35968, P41240, P43403, P45983, P49116, P49841, P51813, P53350, Q02750, Q02763, Q04759, Q13163, Q13233, Q15303, Q16539, Q96GD4, and Q99683