Single-Cell Multiomics Reveals How Gut Microbiota Reprogram Hepatocellular Carcinoma Metabolism to Suppress NK Cell Surveillance Through PRDX1

This study investigates the role of gut microbiota in driving immune evasion in hepatocellular carcinoma (HCC) through peroxiredoxin 1 (PRDX1)-mediated metabolic reprogramming. Using multi-omics analysis of clinical samples and experimental validation in cell and animal models, we demonstrate that HCC patients exhibit significant enrichment of Bacilli and Lactobacillales, which correlates with PRDX1 upregulation (log2FC=2.1, p