CDH11 variant mRNA is translated to CDH11 variant protein isoform

The CDH11 variant mRNA encodes the 85 kDa CDH11 variant protein isoform (CDH11v or CDH11-2), 693 amino acids long. CDH11v includes the extracellular domain, with its five subdomains (ectodomains EC1-EC5), and two thirds of the transmembrane (TM) domain. It lacks the C-terminal third of the TM domain and the cytoplasmic (CP) domain (Okazaki et al. 1994, Kawaguchi et al. 1999).<br><br>CDH11 mRNA levels are downregulated by the microRNA miR-451a (Wang et al. 2020) and miR-200c-3p (Van der Goten et al. 2014). The 3'UTR sequence targeted by miR-451a and miR-200c-3p is present in both the canonical splicing isoform and the variant splicing isoform of CDH11.

CDH11变异型mRNA编码的85 kDa CDH11变异型蛋白异构体（CDH11v或CDH11-2），由693个氨基酸组成。CDH11v包含细胞外区域，及其五个亚结构域（外结构域EC1-EC5）和跨膜（TM）区域的三分之二。它缺少TM区域的C端三分之一和细胞质（CP）区域（参见Okazaki等，1994年，Kawaguchi等，1999年）。CDH11 mRNA水平受到microRNA miR-451a（Wang等，2020年）和miR-200c-3p（Van der Goten等，2014年）的下调。miR-451a和miR-200c-3p靶向的3'非翻译区（UTR）序列存在于CDH11的常规剪接异构体和变异剪接异构体中。