Frequency of deleterious coding and noncoding SNPs.

The alignments and data are the same as those used in Table 4. The number of deleterious SNPs is the difference between the total and neutral number of SNPs. The number of neutral nonsynonymous SNPs is estimated by Non*dNpS/dSpN, where Non is the number of Nonsynonymous SNPs and dN, dS, pN, pS are nonsynonymous and synonymous divergences and polymorphism, respectively. Classes are nonsynonymous (non), synonymous (syn), conserved noncoding (con), unconserved noncoding (uncon). The deleterious fraction is the number of deleterious SNPs divided by the total number of SNPs in the class.