MCM8 interacts with DDX5 to promote R-loop resolution in primordial germ cells
收藏NIAID Data Ecosystem2026-05-01 收录
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We found that the number of primordial germ cells (PGCs) decreased dramatically after MCM8 deficiency due to proliferation defects. We further demonstrated that MCM8 interacted with two known helicases DDX5 and DHX9 in PGCs, and loss of MCM8 led to R-loop accumulation by reducing the retention of these helicases at R-loops, thus inducing genome instability.
创建时间：
2024-01-30
