GQRS
收藏资源简介:
The quadruplex structures formed by guanine rich nucleic acid sequences have received significant attention because of increasing evidence for their role in important biological processes and as therapeutic targets. We have generated several computational tools to predict G-quadruplexes in nucleotide sequences and map them to functionally relevant locations on mRNAs and pre-mRNAs. The G-Quadruplex Resource Site serves as a portal to our suite of software programs and databases for analysis of G-quadruplexes.
富含鸟嘌呤的核酸序列所形成的四链体结构已受到学界广泛关注,这得益于越来越多的研究证据表明,这类结构在诸多重要生物学过程中发挥关键作用,同时亦可作为治疗靶点。 我们开发了多款计算工具,可用于预测核苷酸序列中的G-四链体(G-quadruplex),并将其映射至信使RNA(mRNA)与前体信使RNA(pre-mRNA)上具备功能相关性的位点。 本G-四链体资源站点(G-Quadruplex Resource Site)作为入口,集成了我们用于G-四链体分析的全套软件程序与数据库。




