A Pan-Cancer Single Cell Panorama of Natural Killer Cells

Natural killer (NK) cells play indispensable roles in innate immune responses against tumor progression, but their phenotypic and functional diversities in the tumor microenvironment (TME) remain unclear. Here, we performed integrated analyses on the single-cell RNA sequencing (scRNA-seq) data for NK cells across multiple cancer types. Our study provides new insights into NK cell–based cancer immunity and highlights the potential clinical utilities of NK cell subsets as therapeutic targets. We generated scRNA-seq data from 47 cancer patients to investigate tumor-infiltrating NK cells across multiple cancer types, including tumor and normal tissue. The raw sequencing data were provided at China Genomic Sequence Archive (GSA): HRA000321. NOTE FROM SUBMITTER: The raw sequencing have been uploaded to China Genomic Sequence Archive with accession number GSA: HRA000321 (https://ngdc.cncb.ac.cn/search/?dbId=hra&q=HRA000321).