Data from: Fasting glucose and risk of colorectal cancer in the Korean Multi-center Cancer Cohort

Previous cohort studies have demonstrated a positive association between
diabetes mellitus (DM) and colorectal cancer (CRC). However, there are few
comparisons between groups with controlled DM and uncontrolled DM. This
study examined associations between diabetes as defined by fasting serum
glucose (FSG) levels and self-reported history of DM and CRC risk among
Korean adults. Data from the Korean Multi-center Cancer Cohort between
1993 and 2005 were analyzed. The study population comprised 14,570
participants aged 20 years or older. Participants were followed until
December 31, 2012 (median follow-up: 11.9 years). Among participants with
high FSG (≥126mg/dL), the risk of developing CRC was significantly higher
(HR: 1.51 [1.02-2.25]) than among participants with low FSG
(<126mg/dL). Risk was not significantly higher among participants
with self-reported history of DM (HR: 1.34 [0.78-2.31]). When both FSG and
history of DM were considered together, the risk of CRC was higher among
participants with both high FSG and no history of DM (HR: 1.54
[0.97-2.43]), but was not significantly higher among participants with
both high FSG and a history of DM (HR: 1.50 [0.73-3.05]). When the first 5
years of follow-up were excluded, among participants with high FSG, the
risk of developing CRC was significantly higher (HR: 1.61 [1.02-2.56])
than among participants with low FSG. Risk of CRC was also significantly
higher among participants with high FSG and no history of DM (HR: 1.69
[1.01-2.84]). High FSG and self-reported history of DM were associated
with increased risk of CRC in this Korean population.