Analysis of serum exosomal miRNAs associated with lymph node metastasis in esophageal squamous cell carcinoma

Preoperative prediction of lymph node (LN) metastasis is accepted as an important independent risk factor for treatment decision-making for esophageal squamous cell carcinoma (ESCC) patients. This study aimed to develop a non-invasive biomarker to identify LN metastasis preoperatively in ESCC patients with serum exosomal RNA-seq. Overall design: RNA-seq of serum exosomal RNA collected from ESCC patients with or without lymph node metastasis.