Expression data after PAK2 knockdown in head and neck cancer cells

Epigenetic mechanisms play an important role in the cellular development and maintenance of cellular homeostasis. Any alteration of epigenetic mechanisms via the changes in DNA methylation and histone modification may lead to various diseases including cancer. The differential expression of histone modifiers has been observed in various malignancies. We used microarray to detail the differential gene-expression pattern of head and neck (HNC) cancer cells upon depletion of p21 activated kinase (PAK2). we identified distinct class of downregulated genes, majorly associated with cellular proliferation and tumorigenesis. In this study, we have analyzed the global expression pattern upon PAK2 depletion compared to shControl cells using Affymetrix Human Transcriptome 2.0 platform. Array data was processed by Transcriptome Analysis Console (TAC). The experiment was performed with biological replicates.